NEXT-peak: a normal-exponential two-peak model for peak-calling in ChIP-seq data
نویسندگان
چکیده
منابع مشابه
ChIP-SEQ AND PEAK CALLING
et al details each of these steps and discusses how peak finding tools approach the separate steps very differently (3). A follow up review by Wilbanks et al evaluated the performance of 11 ChIP-seq peak callers nearly all of which are still widely used today (4). Each step can have parameters that can be adjusted by the user, but changing these can significantly affect the final peak lists. Ca...
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Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is an important tool for studying gene regulatory proteins, such as transcription factors and histones. Peak calling is one of the first steps in analysis of these data. Peak-calling consists of two sub-problems: identifying candidate peaks and testing candidate . CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/f...
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Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is an important tool for studying gene regulatory proteins, such as transcription factors and histones. Peak calling is one of the first steps in the analysis of these data. Peak calling consists of two sub-problems: identifying candidate peaks and testing candidate peaks for statistical significance. We surveyed 30 methods and ide...
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UNLABELLED ChIP-seq has become a major tool for the genome-wide identification of transcription factor binding or histone modification sites. Most peak-calling algorithms require input control datasets to model the occurrence of background reads to account for local sequencing and GC bias. However, the GC-content of reads in Input-seq datasets deviates significantly from that in ChIP-seq datase...
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With the advent of next generation high-throughput DNA sequencing technologies, omics experiments have become the mainstay for studying diverse biological effects on a genome wide scale. ChIP-seq is the omics technique that enables genome wide localization of transcription factor binding or epigenetic modification events. Since the inception of ChIP-seq in 2007, many methods have been developed...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2013
ISSN: 1471-2164
DOI: 10.1186/1471-2164-14-349